Aniracetam is a compound that promotes intellectual development and neuroprotection.
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg. Oleoylethanolamide
[1] Said Abd El-Monem Hassan, et al. Spectrofluorimetric study on fluorescence quenching of tyrosine and l-tryptophan by the aniracetam cognition enhancer drug: quenching mechanism using Stern-Volmer and double-log plots
[2] Hannah Phillips, et al. Aniracetam does not improve working memory in neurologically healthy pigeons
[3] Thomas W Elston, et al. Aniracetam does not alter cognitive and affective behavior in adult C57BL/6J mice
[4] Kazuo Nakamura. Aniracetam: its novel therapeutic potential in cerebral dysfunctional disorders based on recent pharmacological discoveries
[5] C R Lee, et al. Aniracetam. An overview of its pharmacodynamic and pharmacokinetic properties, and a review of its therapeutic potential in senile cognitive disorders
(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48).
Emraclidine (CVL-231) is a brain-penetrant muscarinic M4 receptor positive allosteric modulator. Emraclidine can be used for the research of neurological diseases.
ZSET1446 (ST101) is a novel cognitive enhancer that activates T-type voltage-gated calcium channels (VGCCs), and it significantly improves learning deficits in various types of Alzheimer disease (AD) models.
Varenicline (CP 526555, Chantix, Champix) dihydrochloride is a potent, partial agonist of α4β2 nicotinic acetylcholine receptor (nAChR) and α3β4 nAChR with EC50 of 2.3 μM and 55 μM, respectively. Varenicline dihydrochloride is a potent, full agonist of α7 nAChRs with EC50 of 18 μM. Varenicline is a prescription medication used for smoking cessation.
BNC210 (H-Ile-Trp-OH, IW-2143) is a negative allosteric modulator of alpha-7 nicotinic acetylcholine receptor (α7 nAChR).
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